Clinical features, pathophysiology and therapy of Poor Graft Function Post Allogeneic Stem Cell Transplantation.
Ashvind A Prabahran, Rachel Koldej, Lynette Chee, David S Ritchie
Blood Adv | Published : 2021
Poor graft function (PGF) defined by the presence of multi-lineage cytopenias in the presence of 100% donor chimerism, is a serious complication of allogeneic stem cell transplant (alloSCT). Inducers or potentiators of allo-immunity such as CMV reactivation and graft versus host disease (GVHD) are associated with the development of PGF, however more clinical studies are required to establish further risk factors and describe outcomes of PGF. The pathophysiology of PGF can be conceptualized as dysfunction related to the number or productivity of the stem cell compartment, defects in bone marrow microenvironment components such as mesenchymal stromal cells and endothelial cells, or immunologic..View full abstract