Journal article

Influence of BDNF Val66Met polymorphism on excitatory-inhibitory balance and plasticity in human motor cortex

RFH Cash, K Udupa, CA Gunraj, F Mazzella, ZJ Daskalakis, AHC Wong, JL Kennedy, R Chen



OBJECTIVE: While previous studies showed that the single nucleotide polymorphism (Val66Met) of brain-derived neurotrophic factor (BDNF) can impact neuroplasticity, the influence of BDNF genotype on cortical circuitry and relationship to neuroplasticity remain relatively unexplored in human. METHODS: Using individualised transcranial magnetic stimulation (TMS) parameters, we explored the influence of the BDNF Val66Met polymorphism on excitatory and inhibitory neural circuitry, its relation to I-wave TMS (ITMS) plasticity and effect on the excitatory/inhibitory (E/I) balance in 18 healthy individuals. RESULTS: Excitatory and inhibitory indexes of neurotransmission were reduced in Met allele ca..

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University of Melbourne Researchers


Awarded by Canadian Institutes of Health Research

Awarded by Australian Research Council

Funding Acknowledgements

RFHC received support from the Canadian Institutes of Health Research (grant number DFF211888) and Australian Research Council (DE200101708). KU was supported by Canadian Institutes of Health Research (grant number 201010DFF-236001-172378). This work was also supported by Canadian Institutes of Health Research (grant number FDN 154292). In the last 3 years, ZJD received research and equipment in-kind support for an investigator-initiated study through Brainsway Inc and Magventure Inc. ZJD has also served on the advisory board for Sunovion, Hoffmann-La Roche Limited and Merck and received speaker support from Eli Lilly. ZJD was supported by the Ontario Mental Health Foundation (OMHF), the Canadian Institutes of Health Research (CIHR), the Brain and Behaviour Research Foundation and the Temerty Family and Grant Family and through the Centre for Addiction and Mental Health (CAMH) Foundation and the Campbell Institute.