Journal article

The impact of adverse and positive experiences on inflammatory outcomes in Australian and UK children

Shuaijun Guo, Dawid Gondek, Meredith O'Connor, Stephanie Cahill, Marnie Downes, Margarita Moreno-Betancur, David Burgner, Natalie Slopen, Sharon Goldfeld, Melissa Wake, Markus Juonala, Jessica Kerr, Kate Lycett, Yichao Wang, Rebecca Lacey, Naomi Priest

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | OXFORD UNIV PRESS | Published : 2021

Abstract

Abstract Background Inflammation is one of key mechanisms linking childhood experiences to later chronic disease risk. Childhood adversity is associated with inflammation, but little is known about positive experiences. We examine how adverse and positive experiences are associated with inflammatory markers in late childhood, and whether they have an interaction effect. Methods Data sources: Longitudinal Study of Australian Children (LSAC; N = 1237) and Avon Longitudinal Study of Parents and Children (ALSPAC; N = 3488). Exposures: Adverse and positive experiences assessed f..

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