Journal article

314Data-adaptive methods for high-dimensional mediation analysis: Application to a randomised trial of tuberculosis vaccination

Margarita Moreno-Betancur, Nicole L Messina, Kaya Gardiner, Nigel Curtis, Stijn Vansteelandt

International Journal of Epidemiology | Oxford University Press (OUP) | Published : 2021

Abstract

Abstract Focus of Presentation Statistical methods for causal mediation analysis are useful for understanding the pathways by which a certain treatment or exposure impacts health outcomes. Existing methods necessitate modelling of the distribution of the mediators, which quickly becomes infeasible when mediators are high-dimensional (e.g., biomarkers). We propose novel data-adaptive methods for estimating the indirect effect of a randomised treatment that acts via a pathway represented by a high-dimensional set of measurements. This work was motivated by the Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR), a rando..

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