977Mechanistic within-host modelling to fast-track the selection of new antimalarial combination therapies

Abstract

Abstract Background The efficacy of artemisinin-based combination therapies (ACTs), currently the first-line antimalarial treatments, is declining due to the emergence of resistance of malaria parasites to these drugs. This has led drug development initiatives to search for novel combination therapies to replace the failing ACTs. We developed a biologically informed within-host model, validated against data from volunteer infection studies, to guide critical drug development decisions. Methods A within-host model was developed, linking drug concentrations of two novel antim..