Journal article

SOD2 in skeletal muscle: New insights from an inducible deletion model

Aowen Zhuang, Christine Yang, Yingying Liu, Yanie Tan, Simon T Bond, Shannen Walker, Tim Sikora, Adrienne Laskowski, Arpeeta Sharma, Judy B de Haan, Peter J Meikle, Takahiko Shimizu, Melinda T Coughlan, Anna C Calkin, Brian G Drew

REDOX BIOLOGY | ELSEVIER | Published : 2021

Abstract

Metabolic conditions such as obesity, insulin resistance and glucose intolerance are frequently associated with impairments in skeletal muscle function and metabolism. This is often linked to dysregulation of homeostatic pathways including an increase in reactive oxygen species (ROS) and oxidative stress. One of the main sites of ROS production is the mitochondria, where the flux of substrates through the electron transport chain (ETC) can result in the generation of oxygen free radicals. Fortunately, several mechanisms exist to buffer bursts of intracellular ROS and peroxide production, including the enzymes Catalase, Glutathione Peroxidase and Superoxide Dismutase (SOD). Of the latter, the..

View full abstract

Grants

Awarded by National Heart Foundation of Australia, Future Leader Fellowship scheme


Funding Acknowledgements

We acknowledge funding support from the Victorian State Govern-ment OIS program to Baker Heart & Diabetes Institute. BGD and ACC received support from the National Heart Foundation of Australia, Future Leader Fellowship scheme (101789 and 100067, respectively) . We also thank all members of the MMA, LMCD and Metabolomics lab-oratories at BHDI for their ongoing contributions.