Journal article

Smoking methylation marks for prediction of urothelial cancer risk.

Chenglong Yu, Kristina M Jordahl, Julie K Bassett, Jihoon E Joo, Ee Ming Wong, Maree T Brinkman, Daniel F Schmidt, Damien M Bolton, Enes Makalic, Theodore M Brasky, Aladdin H Shadyab, Lesley F Tinker, Anthony Longano, John L Hopper, Dallas R English, Roger L Milne, Parveen Bhatti, Melissa C Southey, Graham G Giles, Pierre-Antoine Dugué

Cancer Epidemiol Biomarkers Prev | Published : 2021

Abstract

BACKGROUND: Self-reported information may not accurately capture smoking exposure. We aimed to evaluate whether smoking-associated DNA methylation markers improve urothelial cell carcinoma (UCC) risk prediction. METHODS: Conditional logistic regression was used to assess associations between blood-based methylation and UCC risk using two matched case-control samples, N=404 pairs from the Melbourne Collaborative Cohort Study (MCCS) and N=440 pairs from the Women's Health Initiative (WHI) cohort, respectively. Results were pooled using fixed-effects meta-analysis. We developed methylation-based predictors of UCC and evaluated their prediction accuracy on two replication datasets using the area..

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Grants

Awarded by HHS | NIH | National Heart, Lung, and Blood Institute


Awarded by Department of Health, Australian Government | National Health and Medical Research Council