Journal article

A critical review of connectome validation studies

Tabinda Sarwar, Kotagiri Ramamohanarao, Andrew Zalesky

NMR IN BIOMEDICINE | WILEY | Published : 2021

Abstract

Diffusion MRI tractography is the most widely used macroscale method for mapping connectomes in vivo. However, tractography is prone to various errors and biases, and thus tractography-derived connectomes require careful validation. Here, we critically review studies that have developed or utilized phantoms and tracer maps to validate tractography-derived connectomes, either quantitatively or qualitatively. We identify key factors impacting connectome reconstruction accuracy, including streamline seeding, propagation and filtering methods, and consider the strengths and limitations of state-of-the-art connectome phantoms and associated validation studies. These studies demonstrate the inhere..

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University of Melbourne Researchers