Journal article
Comparable Glucose Control with Fast-Acting Insulin Aspart Versus Insulin Aspart Using a Second-Generation Hybrid Closed-Loop System During Exercise
Dale Morrison, Dessi P Zaharieva, Melissa H Lee, Barbora Paldus, Sara Vogrin, Benyamin Grosman, Anirban Roy, Natalie Kurtz, David Norman O'Neal
DIABETES TECHNOLOGY & THERAPEUTICS | MARY ANN LIEBERT, INC | Published : 2022
Abstract
Background: This study compared glucose control with fast-acting insulin aspart (FiAsp) versus insulin aspart following moderate-intensity exercise (MIE) and high-intensity exercise (HIE) using a second-generation closed-loop (CL) system in people with type 1 diabetes. Materials and Methods: This randomized crossover study compared FiAsp versus insulin aspart over four sessions during MIE and HIE with CL insulin delivery by the MiniMed™ Advanced hybrid CL system. Participants were randomly assigned FiAsp and insulin aspart each for 6 weeks and within each period performed, in random order, 40 min MIE (∼50% VO2max) and HIE (6 × 2 min ∼80% VO2max; 5 min recovery). The primary outcome was conti..
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Funding Acknowledgements
Funds were provided for this investigator-initiated study by Medtronic and Novo Nordisk. Material support was provided from Medtronic and Novo Nordisk. M.H.L. is supported by a National Health and Medical Research Council (NHMRC) postgraduate scholarship, cofounded by Diabetes Australia. B.P. is supported by a University of Melbourne scholarship and research support from JDRF. D.Z. is supported by the Leona M. and Harry B. Helmsley Charitable Trust and the International Society for Pediatric and Adolescent Diabetes (ISPAD) Fellowship. The funders of the study had no role in the study design; the collection, analysis, and interpretation of data; and writing the report; and did not impose any restriction regarding the publication of the report.