Journal article
Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis
Y Zhan, Y Zhang, S Zhang, H Coughlan, PL Baldoni, N Jacquelot, WHJ Cao, S Preston, C Louis, J Rautela, M Pellegrini, IP Wicks, WS Alexander, LC Harrison, AM Lew, GK Smyth, SL Nutt, M Chopin
Science Immunology | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2021
Abstract
Dendritic cells (DCs) and macrophages are at the forefront of immune responses, modifying their transcriptional programs in response to their tissue environment or immunological challenge. Posttranslational modifications of histones, such as histone H3 lysine-27 trimethylation (H3K27me3) by the Polycomb repressive complex 2 (PRC2), are tightly associated with epigenetic regulation of gene expression. To explore whether H3K27me3 is involved in either the establishment or function of the mononuclear phagocyte system, we selectively deleted core components of PRC2, either EZH2 or SUZ12, in CD11c-expressing myeloid cells. Unexpectedly, EZH2 deficiency neither prevented the deposition and mainten..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia grants 1196235 (M.C.); 1155342 (S.L.N.); 1154970 and 1158531 (G.K.S.); 1150425, 1143976, and 1080321 (A.M.L.); 1058344 (W.S.A.), 1173342 (W.S.A.), 1113577 (W.S.A.), 1150425 (L.C.H.), 1173945 (L.C.H.), and 1113577 (I.P.W.); and 1154325 (I.P.W.). M.C. is supported by the Jenny Thatchell/Pauline Speedy and the Barbara McDonald Innovation grants; H.C. is supported by the Marian and E.H. Flack Fellowship; and Y. Zhang is supported by the National Natural Science Foundation of China (91742109 and 31770978). This work was made possible through the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIIS. I.P.W. acknowledges funding from the Reid Charitable Trusts.