Journal article

Reduction in post-operative pancreatic fistula with polyethylene glycol and recombinant human albumin sealant following stapled distal pancreatectomy

Benjamin J Privett, Marcos V Perini, Laurence Weinberg, Michael A Fink, Vijayaragavan Muralidharan, Eunice Lee, Graham Starkey, Robert Jones, Yi-Ju Lin, Mehrdad Nikfarjam



BACKGROUND: Postoperative pancreatic fistula (POPF) remains a significant cause of morbidity in patients undergoing distal pancreatectomy (DP). The use of polyethylene glycol (PEG) and recombinant human albumin sealant gel applied to the transected pancreatic margin in DP may reduce POPF rates and was assessed. METHODS: A retrospective single centre cohort study of patient undergoing DP at an Australian high volume tertiary institution between January 2015 and January 2021. Rates of POPF in patients undergoing stapled pancreatic transection with PEG sealant were compared to other methods. RESULTS: A total of 54 cases were identified for analysis, with 16 undergoing stapled DP combined with s..

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Funding Acknowledgements

The authors would like to acknowledge the contribution of Ms. Mel Craig for maintaining the prospective surgical database that was accessed for this study. We also acknowledge Pancare Foundation ( for supporting hepatobiliary pancreatic cancer research in the Department of Surgery.