Journal article

Bio-nano Science: Better Metrics Would Accelerate Progress

Matthew Faria, Stuart T Johnston, Andrew J Mitchell, Edmund Crampin, Frank Caruso

Chemistry of Materials | American Chemical Society (ACS) | Published : 2021

Abstract

An early step of evaluating a nanomaterial’s potential for biological applications is investigating its interactions with cells and biological fluids. These experiments generate complex data, which are summarized and analyzed through the use of metrics. Choosing appropriate metrics is thus critical to build a foundation for nanomaterial research. Unfortunately, several widely used metrics in the bio-nano scientific literature have significant issues and may not be delivering their intended insight. This perspective will label and discuss three problematic metrics in wide use within the field: Percentage Cell Association, used to measure the interaction strength between a cell and a nanoengin..

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Grants

Awarded by Australian Research Council Centre of Excellence in Convergent BioNano Science and Technology


Awarded by Australian Research Council


Awarded by National Health and Medical Research Council Senior Principal Research Fellowship


Funding Acknowledgements

This work was conducted and funded by the Australian Research Council Centre of Excellence in Convergent BioNano Science and Technology (Project No. CE140100036). S.T.J. is supported by the Australian Research Council (Project No. DE200100988). F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (GNT1135806). This work was supported by a gift from the estate of Rejane Louise Langlois.