Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease
Md Jakaria, Abdel Ali Belaidi, Ashley I Bush, Scott Ayton
JOURNAL OF NEUROCHEMISTRY | WILEY | Published : 2021
Alzheimer's disease (AD) is the most prevalent form of dementia, with complex pathophysiology that is not fully understood. While β-amyloid plaque and neurofibrillary tangles define the pathology of the disease, the mechanism of neurodegeneration is uncertain. Ferroptosis is an iron-mediated programmed cell death mechanism characterised by phospholipid peroxidation that has been observed in clinical AD samples. This review will outline the growing molecular and clinical evidence implicating ferroptosis in the pathogenesis of AD, with implications for disease-modifying therapies.
We acknowledge funding from the Australian National Health & Medical Research Council (NHMRC). The Florey Institute of Neuroscience and Mental Health acknowledges support from the Victorian Government, in particular, funding from the Operational Infrastructure Support Grant. MJ is supported by an Australian Government Research Training Program (RTP) Stipend and RTP Fee-Offset Scholarship through the University of Melbourne, Australia. Figures were created with BioRender.com