Journal article

Outcomes of Echocardiography-Detected Rheumatic Heart Disease: Validating a Simplified Score in Cohorts From Different Countries

Bruno R Nascimento, Maria Carmo P Nunes, Emily M Lima, Amy E Sanyahumbi, Nigel Wilson, Elizabeth Tilton, Marc GW Remond, Graeme P Maguire, Antonio Luiz P Ribeiro, Peter N Kazembe, Craig Sable, Andrea Z Beaton

JOURNAL OF THE AMERICAN HEART ASSOCIATION | WILEY | Published : 2021

Abstract

Background The natural history of latent rheumatic heart disease (RHD) detected by echocardiography remains unclear. We aimed to assess the accuracy of a simplified score based on the 2012 World Heart Federation criteria in predicting mid-term RHD echocardiography outcomes in children from 4 different countries. Methods and Results Patient-level baseline and follow-up data of children with latent RHD from 4 countries (Australia, n=62; Brazil, n=197; Malawi, n=40; New Zealand, n=94) were combined. A simplified echocardiographic scoring system previously developed from Brazilian and Ugandan cohorts, consisting of 5 point-based variables with respective weights, was applied: mitral valveanterio..

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University of Melbourne Researchers

Grants

Awarded by CNPq (Bolsa de produtividade em pesquisa)


Awarded by FAPEMIG (Programa Pesquisador Mineiro)


Awarded by FAPEMIG


Awarded by National Institute of Science and Technology for Health Technology Assessment (IATS)


Funding Acknowledgements

The PROVAR+ investigators would like to thank Edwards Lifesciences Foundation (R) for supporting and funding the primary care screening program (PROVAR+) in Brazil, General Electric Healthcare (R) for providing echocardiography equipment and WiRed Health Resources for providing online curriculum on heart disease and echocardiography. The Telehealth Network of Minas Gerais was funded by the State Government of Minas Gerais, by its Health Department (Secretaria de Estado da Saude de Minas Gerais) and FAPEMIG (Fundacao de Amparo a Pesquisa de Minas Gerais), and by the Brazilian Government, including the Health Ministry and the Science and Technology Ministry and its research and innovation agencies, CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) e FINEP (Financiadora de Estudos e Projetos). Dr Ribeiro was supported in part by CNPq (Bolsa de produtividade em pesquisa, 310679/2016-8) and by FAPEMIG (Programa Pesquisador Mineiro, PPM-00428-17). Dr Nascimento was supported in part by CNPq (Bolsa de produtividade em pesquisa, 312382/2019-7), by the Edwards Lifesciences Foundation (Every Heartbeat Matters Program 2020) and by FAPEMIG (grant APQ-000627-20). Medical students received scholarships from the National Institute of Science and Technology for Health Technology Assessment (IATS, project: 465518/2014-1).