Disruptions in white matter microstructure associated with impaired visual associative memory in schizophrenia-spectrum illness
Cassandra MJ Wannan, Cali F Bartholomeusz, Christos Pantelis, Maria A Di Biase, Warda T Syeda, M Mallar Chakravarty, Chad A Bousman, Ian P Everall, Patrick D McGorry, Andrew Zalesky, Vanessa L Cropley
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | SPRINGER HEIDELBERG | Published : 2021
Episodic memory ability relies on hippocampal-prefrontal connectivity. However, few studies have examined relationships between memory performance and white matter (WM) microstructure in hippocampal-prefrontal pathways in schizophrenia-spectrum disorder (SSDs). Here, we investigated these relationships in individuals with first-episode psychosis (FEP) and chronic schizophrenia-spectrum disorders (SSDs) using tractography analysis designed to interrogate the microstructure of WM tracts in the hippocampal-prefrontal pathway. Measures of WM microstructure (fractional anisotropy [FA], radial diffusivity [RD], and axial diffusivity [AD]) were obtained for 47 individuals with chronic SSDs, 28 FEP ..View full abstract
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Awarded by National Health and Medical Research Council
Awarded by Brain and Behavior Research Foundation
This study was funded by National Health and Medical Research Council (Grant numbers 1105825, 1150083 and 1177370) and Brain and Behavior Research Foundation (Grant number 21660).