Journal article

The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study

Oemer Faruk Oeztuerk, Alessandro Pigoni, Julian Wenzel, Shalaila S Haas, David Popovic, Anne Ruef, Dominic B Dwyer, Lana Kambeitz-Ilankovic, Stephan Ruhrmann, Katharine Chisholm, Paris Lalousis, Sian Lowri Griffiths, Theresa Lichtenstein, Marlene Rosen, Joseph Kambeitz, Frauke Schultze-Lutter, Peter Liddle, Rachel Upthegrove, Raimo KR Salokangas, Christos Pantelis Show all

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | SPRINGER HEIDELBERG | Published : 2021

Abstract

BACKGROUND: Formal thought disorder (FTD) has been associated with more severe illness courses and functional deficits in patients with psychotic disorders. However, it remains unclear whether the presence of FTD characterises a specific subgroup of patients showing more prominent illness severity, neurocognitive and functional impairments. This study aimed to identify stable and generalizable FTD-subgroups of patients with recent-onset psychosis (ROP) by applying a comprehensive data-driven clustering approach and to test the validity of these subgroups by assessing associations between this FTD-related stratification, social and occupational functioning, and neurocognition. METHODS: 279 pa..

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Grants

Awarded by Structural European Funding of the Italian Minister of Education (Attraction and International Mobility-AIM-action)


Funding Acknowledgements

We thank all subjects for their participation in the study. Oemer Faruk Oeztuerk and David Popovic are supported by International Max Planck Research School for Translational Psychiatry in the frame of Clinician Scientist Program funded by the Else-Kroner-Fresenius-Stiftung. Linda A. Antonucci's salary is funded by the Structural European Funding of the Italian Minister of Education (Attraction and International Mobility-AIM-action, grant agreement No 1859959).