Association between cognitive trajectories and disability progression in patients with relapsing-remitting multiple sclerosis

Abstract

Background and Objectives Longitudinal cognitive trajectories in multiple sclerosis are heterogeneous and difficult to measure. We aimed to identify discrete longitudinal reaction time trajectories in relapsingremitting multiple sclerosis using a computerized cognitive battery and to assess the association between trajectories of reaction time and disability progression. Methods All participants serially completed computerized reaction time tasks measuring psychomotor speed, visual attention, and working memory. Participants completed at least 3 testing sessions over a minimum of 180 days. Longitudinal reaction times were modeled with latent class mixed models to identify groups of individua..