Analgesic use and the risk of renal cell carcinoma – Findings from the Consortium for the Investigation of Renal Malignancies (CONFIRM) study

FJ Bruinsma; S Jordan; JK Bassett; G Severi; RJ MacInnis; J Walsh; T Aitken; M Jenkins; R Carroll; M Jefford; ID Davis; K Tucker; T Dudding-Byth; DR English; GG Giles; I Winship; RL Milne

Journal article

Analgesic use and the risk of renal cell carcinoma – Findings from the Consortium for the Investigation of Renal Malignancies (CONFIRM) study

FJ Bruinsma, S Jordan, JK Bassett, G Severi, RJ MacInnis, J Walsh, T Aitken, M Jenkins, R Carroll, M Jefford, ID Davis, K Tucker, T Dudding-Byth, DR English, GG Giles, I Winship, RL Milne

Cancer Epidemiology | ELSEVIER SCI LTD | Published : 2021

DOI: 10.1016/j.canep.2021.102036

Abstract

Purpose: The incidence of renal cell carcinoma (RCC) is rising. Use of analgesics such as non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol may affect renal function. The aim of this study was to assess associations between analgesic use and risk of RCC. Methods: A population-based case-control family design was used. Cases were recruited via two Australian state cancer registries. Controls were siblings or partners of cases. Analgesic use was captured by self-completed questionnaire. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for RCC risk associated with regular analgesic use (at least 5 times per month for 6 months or more) and ..

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University of Melbourne Researchers

Fiona Bruinsma Author

Robert MacInnis Author

Mark Jenkins Author

Michael Jefford Author

Related Projects (1)

COLLABORATIVE AUSTRALIAN RENAL CELL CARCINOMA EIPDEMIOLOGY STUDY CARES

The objective of this project is to increase our knowledge of the causes of renal cell carcinoma, a relatively common, yet understudied, can..

Grants

Awarded by Victorian Cancer Agency

Funding Acknowledgements

The CONFIRM Study was funded by grants from The Victorian Cancer Agenc, Australia (Grant ID PTCB08_05) and the National Health and Medical Research Council, Australia (Project Grant ID 1011626). IDD was supported by an NHMRC Practitioner Fellowship (APP1102604). Funding sources did not have any role in the design, collection, analysis, interpretation or writing of the report.