Journal article

Lipidomic Signatures of Changes in Adiposity: A Large Prospective Study of 5849 Adults from the Australian Diabetes, Obesity and Lifestyle Study

Habtamu B Beyene, Gavriel Olshansky, Corey Giles, Kevin Huynh, Michelle Cinel, Natalie A Mellett, Adam Alexander T Smith, Jonathan E Shaw, Dianna J Magliano, Peter J Meikle

METABOLITES | MDPI | Published : 2021

Abstract

Lipid metabolism is tightly linked to adiposity. Comprehensive lipidomic profiling offers new insights into the dysregulation of lipid metabolism in relation to weight gain. Here, we investigated the relationship of the human plasma lipidome and changes in waist circumference (WC) and body mass index (BMI). Adults (2653 men and 3196 women), 25-95 years old who attended the baseline survey of the Australian Diabetes, Obesity and Lifestyle Study (AusDiab) and the 5-year follow-up were enrolled. A targeted lipidomic approach was used to quantify 706 distinct molecular lipid species in the plasma samples. Multiple linear regression models were used to examine the relationship between the baselin..

View full abstract

Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

National Health and Medical Research Council of Australia (Project grant APP1101320) and the Victorian Government's Operational Infrastructure Support Program. JES and DJM are supported by an Investigator Grant and a Senior Research Fellowship, respectively, from the National Health and Medical Research Council of Australia. H.B.B. was supported by the Baker institute and Monash University Scholarships.