Journal article
Stability of ZIF-8 nanopowders in bacterial culture media and its implication for antibacterial properties
M Taheri, D Ashok, T Sen, TG Enge, NK Verma, A Tricoli, A Lowe, D R. Nisbet, T Tsuzuki
Chemical Engineering Journal | Published : 2021
Abstract
The stability and degradation characteristics of metal–organic frameworks (MOFs) in liquid media dictate their use in biomedical engineering applications. In this study, the antibacterial property of a zinc-based MOF, zeolite imidazolate framework-8 (ZIF-8), against gram-negative Escherichia coli (E. coli) is studied in comparison with ZnO, a widely-used antimicrobial agent. Superior antibacterial property of ZIF-8 was demonstrated and the reason was elucidated by new insights on the stability of ZIF-8 in bacterial culture media. Contrary to the widely held notion that ZIF-8 is stable in aqueous media, inductively coupled plasma-optical emission spectrometry and UV–Vis adsorption spectroscop..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
MT would like to thank the PhD research fellowship from the Australian National University. DRN was supported by a NHMRC Dementia Research Leadership Fellowship (APP1135687) . Access to the facilities of the Centre for Advanced Microscopy (CAM) with funding through the Australian Microscopy and Microanalysis Research Facility (AMMRF) is gratefully acknowledged.