Journal article
The EUS molecular evaluation of pancreatic cancer: A prospective multicenter cohort trial
S Masoumi-Moghaddam, J Lundy, H Gao, V Rathi, M Swan, C Desmond, M Bhutani, M Southey, R Vaughan, P Varma, P Tagkalidis, B Holt, CC Pilgrim, E Segelov, B Lee, M Harris, A Strickland, S Frentzas, J Zalcberg, B Jenkins Show all
Endoscopic Ultrasound | Published : 2021
Abstract
Background and Objectives: Patients with locally advanced or metastatic pancreatic ductal adenocarcinoma (A-PDAC) are not candidates for surgical resection and are often offered palliative chemotherapy. The ready availability of a safe and effective tumor sampling technique to provide material for both diagnosis and comprehensive genetic profiling is critical for informing precision medicine in A-PDAC, thus potentially increasing survival. The aim of this study is to examine the feasibility and benefits of routine comprehensive genomic profiling (CGP) of A-PDAC using EUS-FNA material. Methods: This is a prospective cohort study to test the clinical utility of fresh frozen or archival EUS-FNA..
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Awarded by Victorian Cancer Agency
Funding Acknowledgements
This study is an extension of an already ongoing research, funded by the Victorian Cancer Agency grant number M17001 3167532, to further incorporate CGP of PDAC. Additional funding for this component of the project may be provided from a bequest to Monash Health towards pancreatic cancer research. An application for access to these funds will be submitted as required.