Conference Proceedings

732 TUMOR INFILTRATING NEUTROPHILS ARE A POOR PROGNOSTIC MARKER FOR ESOPHAGEAL CANCER PATIENTS RECEIVING NEOADJUVANT CHEMORADIOTHERAPY

Carlos Cabalag, Owen Prall, John Ciciulla, Laurence Galea, Niko Thio, Lynn Chong, Michael W Hii, Paul J Neeson, Gisela Mir Arnau, Wayne A Phillips, Nicholas J Clemons, Cuong P Duong

Diseases of the Esophagus | Oxford University Press (OUP) | Published : 2021

Abstract

Abstract   Significant advances have been made in our understanding of the tumor immune microenvironment (TIM) and tumor infiltrating lymphocytes (TILs). Nevertheless, there is little understanding of the changes in the TIM in response to neoadjuvant chemoradiotherapy (CRT). Thus, our aim was to investigate the changes in the TIM with neoadjuvant CRT in EC by assessing the immune cell infiltrate, the expression of immune related genes, and their association with treatment response and prognosis. Methods To decipher the effects of neoadjuvant CRT on the TIM, we obtained 58 p..

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