Modulation of Vagal Sensory Neurons via High Mobility Group Box-1 and Receptor for Advanced Glycation End Products: Implications for Respiratory Viral Infections
Stuart B Mazzone, Seung-Kwon Yang, Jennifer A Keller, Juste Simanauskaite, Jaisy Arikkatt, Matthew J Fogarty, Aung Aung Kywe Moe, Chen Chen, Matthew W Trewella, Luyi Tian, Matthew E Ritchie, Brendan Y Chua, Simon Phipps, Kirsty R Short, Alice E McGovern
FRONTIERS IN PHYSIOLOGY | FRONTIERS MEDIA SA | Published : 2021
Vagal sensory neurons contribute to the symptoms and pathogenesis of inflammatory pulmonary diseases through processes that involve changes to their morphological and functional characteristics. The alarmin high mobility group box-1 (HMGB1) is an early mediator of pulmonary inflammation and can have actions on neurons in a range of inflammatory settings. We hypothesized that HMGB1 can regulate the growth and function of vagal sensory neurons and we set out to investigate this and the mechanisms involved. Culturing primary vagal sensory neurons from wildtype mice in the presence of HMGB1 significantly increased neurite outgrowth, while acute application of HMGB1 to isolated neurons under patc..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was supported by grants and fellowship awards to SM, AEM, and KS from the National Health and Medical Research Council of Australia (APP1078943, APP1025589, and APP1161029).