Characterization and prediction of clinical pathways of vulnerability to psychosis through graph signal processing

Corrado Sandini; Daniela Zoller; Maude Schneider; Anjali Tarun; Marco Armondo; Barnaby Nelson; Paul G Amminger; Hok Pan Yuen; Connie Markulev; Monica R Schaffer; Nilufar Mossaheb; Monika Schlogelhofer; Stefan Smesny; Ian B Hickie; Gregor Emanuel Berger; Eric YH Chen; Lieuwe de Haan; Dorien H Nieman; Merete Nordentoft; Anita Riecher-Rossler; Swapna Verma; Andrew Thompson; Alison Ruth Yung; Patrick D McGorry; Dimitri Van De Ville; Stephan Eliez

Journal article

Characterization and prediction of clinical pathways of vulnerability to psychosis through graph signal processing

Corrado Sandini, Daniela Zoller, Maude Schneider, Anjali Tarun, Marco Armondo, Barnaby Nelson, Paul G Amminger, Hok Pan Yuen, Connie Markulev, Monica R Schaffer, Nilufar Mossaheb, Monika Schlogelhofer, Stefan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric YH Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rossler Show all

ELIFE | eLIFE SCIENCES PUBL LTD | Published : 2021

DOI: 10.7554/eLife.59811.sa2

Abstract

Causal interactions between specific psychiatric symptoms could contribute to the heterogenous clinical trajectories observed in early psychopathology. Current diagnostic approaches merge clinical manifestations that co-occur across subjects and could significantly hinder our understanding of clinical pathways connecting individual symptoms. Network analysis techniques have emerged as alternative approaches that could help shed light on the complex dynamics of early psychopathology. The present study attempts to address the two main limitations that have in our opinion hindered the application of network approaches in the clinical setting. Firstly, we show that a multi-layer network analysis..

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University of Melbourne Researchers

Hok Yuen Author Centre for Youth Mental Health

Connie Markulev Author Centre for Youth Mental Health

Andrew Thompson Author Centre for Youth Mental Health

Patrick McGorry Author Centre for Youth Mental Health

Barnaby Nelson Author Centre for Youth Mental Health

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Grants

Awarded by Stanley Medical Research Institute

Awarded by National Health and Medical Research Council

Awarded by Schweizerischer Nationalfonds zur Fo rderung der Wissenschaftlichen Forschung

Funding Acknowledgements

Stanley Medical Research Institute 07TGF-1102 Barnaby Nelson Paul G Amminger Hok Pan Yuen Connie Markulev Monica R Scha ffer Nilufar Mossaheb Monika Schlo gelhofer Stefan Smesny Ian B Hickie Gregor Emanuel Berger Eric YH Chen Lieuwe de Haan Dorien H Nieman Merete Nordentoft Anita Riecher-Rossler Swapna Verma Andrew Thompson Alison Ruth Yung Patrick D McGorryNational Health and Medical Research Council 566529 Ian B Hickie Alison Ruth YungNational Health and Medical Research Council 1060996 Patrick D McGorryNational Health and Medical Research Council 1080963 Alison Ruth Yung Patrick D McGorryNational Health and Medical Research Council 566593 Alison Ruth Yung Patrick D McGorryNational Health and Medical Research Council 1027532 Barnaby NelsonSchweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung FNS 320030_179404 Stephan EliezSchweizerischer Nationalfonds zur Fo rderung der Wissenschaftlichen Forschung FNS 324730_144260 Stephan EliezSchweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung PZ00P1_174206 MaudeSchneider Schweizerischer Nationalfonds zur Fo rderung der Wissenschaftlichen Forschung 51NF40-158776 Stephan EliezThe funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.