Journal article

Reliability and Convergent Construct Validity of Quantitative Ultrasound for Synovitis, Meniscal Extrusion, and Osteophyte in Knee Osteoarthritis With MRI

Win Min Oo, James M Linklater, Kim L Bennell, Matthew S Daniel, Danielle Pryke, Xia Wang, Shirley P Yu, Leticia Deveza, Vicky Duong, David J Hunter



AIMS: To determine: 1) inter-rater reliability of quantitative measurements of ultrasound-detected synovitis, meniscal extrusion, and osteophytes; and 2) construct (convergent) validity via correlations and absolute agreements between ultrasound- and gold-standard magnetic resonance imaging (MRI)-outcomes in knee osteoarthritis. METHODS: Dynamic ultrasound images for supra-patellar synovitis, meniscal extrusion, and osteophytes were acquired and quantified by a physician operator, musculoskeletal ultrasonographer, and medical student independently. On the same day, 3T MRI images were acquired. Effusion-synovitis, meniscal extrusion, and osteophytes were quantified on sagittal or coronal prot..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council

Awarded by NHMRC

Funding Acknowledgements

This study was funded by the National Health and Medical Research Council (ID: 1106274). We acknowledge Canon Medical Systems for providing the Toshiba ultrasound machine and the study participants. Win Min Oo is supported by a Presidential scholarship of Myanmar for his PhD course. DJH is supported by an NHMRC Investigator Grant (1194737), KLB is supported by an NHMRC Investigator grant (#1174431), SY is supported by the University of Sydney Postgraduate Scholarship (Merck PhD Scholarship in Medicine), VD is supported by a University of Sydney Postgraduate Award scholarship.