Journal article

Higher Levels of Circulating Osteoprogenitor Cells Are Associated With Higher Bone Mineral Density and Lean Mass in Older Adults: A Cross-Sectional Study

Jack Feehan, Cassandra Smith, Nicholas Tripodi, Elizabeth Degabrielle, Ahmed Al Saedi, Sara Vogrin, Gustavo Duque, Itamar Levinger

JBMR PLUS | WILEY | Published : 2021

Abstract

Circulating osteo progenitor (COP) cells are a heterogeneous population of cells that circulate within the peripheral blood with characteristics of the bone marrow mesenchymal stem and progenitor pool. Little is known about the behavior of this cell population in humans. The aim of this study was to identify whether a relationship exists between COP cells (as a percentage of the peripheral blood monocytic cells) and musculoskeletal morphometry and to identify if COP have potential clinical utility as a biomarker for osteoporosis. We recruited 57 older adults (median age: 69 years; IQR: 65, 75 years) living independently in the community and performed cross-sectional analysis to identify asso..

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Grants

Funding Acknowledgements

Further This work was supported by a Seed Grant from the Australian Institute for Musculoskeletal Science (AIMSS).Authors' roles: JF: conceptualization, formal analysis, investigation, data curation, project administration, visualization, writing -original draft; CS: conceptualization, investigation, data curation, project administration, writing -review and editing; NT: investigation, writing -review and editing; ED: investigation; AAS: investigation; GD: conceptualization, supervision, funding acquisition, writing -review and editing; IL: conceptualization, supervision, funding acquisition, writing -review and editing.