A hypervariable genomic island identified in clinical and environmental Mycobacterium avium subsp hominissuis isolates from Germany
Andrea Sanchini, Torsten Semmler, Lei Mao, Narender Kumar, Flavia Dematheis, Kshitij Tandon, Vidyullatha Peddireddy, Niyaz Ahmed, Astrid Lewin
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | ELSEVIER GMBH, URBAN & FISCHER VERLAG | Published : 2016
Mycobacterium avium subsp. hominissuis (MAH) is an opportunistic human pathogen widespread in the environment. Genomic islands (GI)s represent a part of the accessory genome of bacteria and influence virulence, drug-resistance or fitness and trigger bacterial evolution. We previously identified a novel GI in four MAH genomes. Here, we further explored this GI in a larger collection of MAH isolates from Germany (n=41), including 20 clinical and 21 environmental isolates. Based on comparative whole genome analysis, we detected this GI in 39/41 (95.1%) isolates. Although all these GIs integrated in the same insertion hotspot, there is high variability in the genetic structure of this GI: eight ..View full abstract
Awarded by German Research Foundation (DFG)
AS received a grant from the German Research Foundation (DFG)-sponsored International Research Training Group (IRTG) entitled Internationales Graduiertenkolleg - Functional Molecular Infection Epidemiology - GRK1673 (Berlin-Hyderabad)'.