Journal article

Design of an inhibitor ofHelicobacter pyloricholesteryl-alpha-glucoside transferase critical for bacterial colonization

Soumiya Pal, Nishat Sarker, Majjid Qaria, Kshitij Tandon, Yusuf Akhter, Niyaz Ahmed

HELICOBACTER | WILEY | Published : 2020

Abstract

BACKGROUND: Fifty percent of the world's population surves as a host for Helicobacter pylori, gastric cancer causing bacteria, that colonizes the gastric region of digestive tract. It has a remarkable capacity to infect the host stomach for the entire lifetime despite an activated host immune response. METHODS: In this study, we have performed the virtual screening analysis of protein-inhibitor binding between the glycosyl transferase enzymes of Helicobacter pylori (CapJ or HP0421) and a corresponding library of inhibitors in the known substrate-binding pockets. We have docked our library of ligands consisting of cholesterol backbone with CapJ protein and identified several ligands' interact..

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University of Melbourne Researchers