Journal article

Assessing the Relative Value of CT Perfusion Compared to Non-contrast CT and CT Angiography in Prognosticating Reperfusion-Eligible Acute Ischemic Stroke Patients

Andrew Bivard, Christopher Levi, Longting Lin, Xin Cheng, Richard Aviv, Neil J Spratt, Tim Kleinig, Kenneth Butcher, Chushuang Chen, Qiang Dong, Mark Parsons

FRONTIERS IN NEUROLOGY | FRONTIERS MEDIA SA | Published : 2021

Abstract

In the present study we sought to measure the relative statistical value of various multimodal CT protocols at identifying treatment responsiveness in patients being considered for thrombolysis. We used a prospectively collected cohort of acute ischemic stroke patients being assessed for IV-alteplase, who had CT-perfusion (CTP) and CT-angiography (CTA) before a treatment decision. Linear regression and receiver operator characteristic curve analysis were performed to measure the prognostic value of models incorporating each imaging modality. One thousand five hundred and sixty-two sub-4.5 h ischemic stroke patients were included in this study. A model including clinical variables, alteplase ..

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Grants

Awarded by National Health and Medical Research Council Australia Partnership Project Grant


Awarded by Career Development, and Future Leader Fellowship


Awarded by National Health and Medical Research Council Practitioner Fellowship


Funding Acknowledgements

This project was supported by a National Health and Medical Research Council Australia Partnership Project Grant (APP1013719). NS funded by a National Health and Medical Research Council, National Heart Foundation cofunded Career Development, and Future Leader Fellowship (APPS1110629/100827). CL was funded by a National Health and Medical Research Council Practitioner Fellowship (APP 1043913).