Journal article
Regulation of gene expression via translational buffering
Eric P Kusnadi, Clelia Timpone, Ivan Topisirovic, Ola Larsson, Luc Furic
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | ELSEVIER | Published : 2022
Abstract
Translation of an mRNA represents a critical step during the expression of protein-coding genes. As mechanisms governing post-transcriptional regulation of gene expression are progressively unveiled, it is becoming apparent that transcriptional programs are not fully reflected in the proteome. Herein, we highlight a previously underappreciated post-transcriptional mode of regulation of gene expression termed translational buffering. In principle, translational buffering opposes the impact of alterations in mRNA levels on the proteome. We further describe three types of translational buffering: compensation, which maintains protein levels e.g. across species or individuals; equilibration, whi..
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
Awarded by Victorian Cancer Agency Early Career Research Fellowship
Awarded by Canadian Institutes of Health Research (CIHR)
Funding Acknowledgements
This work was supported by a National Health and Medical Research Council (NHMRC) of Australia project grant (APP1141339) to LF, IT, OL, a Victorian Cancer Agency Early Career Research Fellowship (ECRF20018) to E.P.K and a University of Melbourne's Melbourne International Research Scholarship (MIRS) to C.T. Work covered in this review has been in part funded by a Canadian Institutes of Health Research (CIHR; CIHR grant MOP-363027) to I.T. who is a Research Scholar (Senior) of Fonds de Recherche du Quebec-Sante (FRQ-S); and by the Swedish Research Council, The Swedish Cancer Society and the Wallenberg Academy Fellow program to O.L. We apologize to the authors of many primary research papers not cited here due to space constraints but whose work influenced our understanding substantively.