Cationic Antimicrobial Peptides Are Leading the Way to Combat Oropathogenic Infections

B Lin; R Li; TNG Handley; JD Wade; W Li; NM O'Brien-Simpson

Journal article

Cationic Antimicrobial Peptides Are Leading the Way to Combat Oropathogenic Infections

B Lin, R Li, TNG Handley, JD Wade, W Li, NM O'Brien-Simpson

ACS Infectious Diseases | Published : 2021

DOI: 10.1021/acsinfecdis.1c00424

Abstract

Oral dental infections are one of the most common diseases affecting humans, with caries and periodontal disease having the highest incidence. Caries and periodontal disease arise from infections caused by oral bacterial pathogens. Current misuse and overuse of antibiotic treatments have led to the development of antimicrobial resistance. However, recent studies have shown that cationic antimicrobial peptides are a promising family of antibacterial agents that are active against oral pathogenic bacteria and also possess less propensity for development of antimicrobial resistance. This timely Review has a focus on two primary subjects: (i) the oral bacterial pathogens associated with dental i..

View full abstract

University of Melbourne Researchers

Wenyi Li Author

Neil O'Brien-Simpson Author

Related Projects (5)

Structurally Nanoengineered Antimicrobial Polypeptide Particles (SNAPPs)

This project aims to develop a new platform technology for the development of antimicrobial agents by combining expertise in polymer science..

STAR POLYMERS AS NOVEL ANTIMICROBIAL AND IMMUNOMODULATORY AGENTS

The rise in antibiotic resistance in bacteria is considered as a major public health threat that is not being met by antibiotic research. Th..

Structurally Nanoengineered Antimicrobial Polypeptide Particles (SNAPPs)

This project aims to develop a new platform technology for the development of antimicrobial agents by combining expertise in polymer science..

Nanoengineering materials to combat antimicrobial resistance

LIVE CELL SUPER RESOLUTION IMAGING FACILITY

Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by grants to W.L. (University of Melbourne Early Career Researcher Grant, Weary Dunlop Foundation Grant and Australian Dental Research Foundation Grant 2545-2020). J.D.W. is supported by an NHMRC Principal Research Fellowship (APP1117483). N.M.O.-S. is supported by NHMRC funding (APP1142472, APP1158841, APP1185426), ARC funding (DP210102781, DP160101312, LE200100163), and Australian Dental Research Funding in antimicrobial materials. This research is supported by the Centre for Oral Health Research at The Melbourne Dental School.