Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians

Luca Hensen; Thi HO Nguyen; Louise C Rowntree; Timon Damelang; Marios Koutsakos; Malet Aban; Aeron Hurt; Kim L Harland; Maria Auladell; Carolien E van de Sandt; Anngie Everitt; Cath Blacker; Damian A Oyong; Jessica R Loughland; Jessica R Webb; Bruce D Wines; P Mark Hogarth; Katie L Flanagan; Magdalena Plebanski; Adam Wheatley; Amy W Chung; Stephen J Kent; Adrian Miller; E Bridie Clemens; Peter C Doherty; Jane Nelson; Jane Davies; Steven YC Tong; Katherine Kedzierska

Journal article

Robust and prototypical immune responses toward influenza vaccines in the high-risk group of Indigenous Australians

Luca Hensen, Thi HO Nguyen, Louise C Rowntree, Timon Damelang, Marios Koutsakos, Malet Aban, Aeron Hurt, Kim L Harland, Maria Auladell, Carolien E van de Sandt, Anngie Everitt, Cath Blacker, Damian A Oyong, Jessica R Loughland, Jessica R Webb, Bruce D Wines, P Mark Hogarth, Katie L Flanagan, Magdalena Plebanski, Adam Wheatley Show all

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2021

DOI: 10.1073/pnas.2109388118

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Abstract

Morbidity and mortality rates from seasonal and pandemic influenza occur disproportionately in high-risk groups, including Indigenous people globally. Although vaccination against influenza is recommended for those most at risk, studies on immune responses elicited by seasonal vaccines in Indigenous populations are largely missing, with no data available for Indigenous Australians and only one report published on antibody responses in Indigenous Canadians. We recruited 78 Indigenous and 84 non-Indigenous Australians vaccinated with the quadrivalent influenza vaccine into the Looking into InFluenza T cell immunity - Vaccination cohort study and collected blood to define baseline, early (day 7..

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University of Melbourne Researchers

Amy Chung Author Microbiology and Immunology

Steven Tong Author Infectious Diseases

Adam Wheatley Author Microbiology and Immunology

Stephen Kent Author Microbiology and Immunology

Louise Rowntree Author Microbiology and Immunology

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Awarded by Australian National Health and Medical Research Council (NHMRC) Program

Awarded by NHMRC

Awarded by Clifford Craig Foundation Grant

Awarded by NHMRC Program

Awarded by NHMRC Senior Research Fellowship

Awarded by NHMRC Senior Principal Research Fellowship

Awarded by European Union

Funding Acknowledgements

We thank all the participants involved in the study and Quitaysha Thompson and Tasha Cole for support with the cohort. Thiswork was supported by Australian National Health and Medical Research Council (NHMRC) Program Grant 1071916 to K.K.; NHMRC Project Grant 1122524 to K.K., S.Y.C.T., and A.M.; NHMRC Project Grant 1141840 to M.P. and K.L.F.; Clifford Craig Foundation Grant 145 to K.L.F.; and NHMRC Investigator Grant 1173871 to K.K. E.B.C. is an NHMRC Peter Doherty Fellow. S.Y.C.T. is an NHMRC Career Development Fellow (1145033) . This work is supported by NHMRC Program Grant 1149990 (S.J.K.) and NHMRC Project Grant 1162760 (A.W.) . K.K. is supported by an NHMRC Senior Research Fellowship (1102792) and S.J.K. by an NHMRC Senior Principal Research Fellowship (1136322) . L.H. is supported by the Melbourne International Research Scholarship and the Melbourne International Fee Remission Schol-arship from The University of Melbourne. C.E.v.d.S. has received funding from the European Union's Horizon 2020 research and innovation pro-gramme under Marie Skodowska-Curie Grant Agreement 792532. The Mel-bourne WHO Collaborating Centre for Reference Research on Influenza is supported by the Australian Government Department of Health.