Thesis / Dissertation

Reprogramming tumour immune microenvironment of colorectal liver metastases with renin-angiotensin inhibitors

Dora Lucia Vallejo Ardila, Sophie Paquet-Fifield (ed.)

Published : 2021

Abstract

Background Renin-angiotensin system inhibitors (RASi) have shown anti-tumour effects that may significantly impact the response to current cancer immunotherapies and the prognosis in patients with colorectal liver metastases (CLM). RAS components are expressed by various immune cells and adult hematopoietic cells. The mechanisms by which RASi reprogram the tumour immune microenvironment toward an immunostimulatory milieu involves modulating the function of immune T lymphocytes, myeloid cells and cancer-associated fibroblasts. Experimental Design Liver metastases were established in a mouse model using an autologous colorectal cancer cell line. RASi captopril 750mg/kg or saline was administe..

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