Thesis / Dissertation

MRGPRX2 and its role in drug-induced anaphylaxis

Nithya Asiri Fernandopulle, Graham Mackay (ed.)

Published : 2021

Abstract

Drug-induced anaphylaxis is a growing concern with both the better characterised IgE-dependent mechanism and less well-established IgE-independent mechanisms being implicated. IgE-independent anaphylaxis has recently been suggested to be associated with direct mast cell activation via the newly identified G protein-coupled receptor, MRGPRX2. While the clinical relevance of the receptor is not yet well understood, a range of polybasic agonists, including therapeutic drugs like neuromuscular blocking agents (NMBAs), have been found to be agonists at the receptor. Presumably, mast cells in all humans express MRGPRX2, therefore the reason why only certain individuals are susceptible to sometimes..

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