Thesis / Dissertation

Roles of nicotinic acetylcholine receptors in development, viability, and insecticide response, in Drosophila melanogaster

Danielle Maree Christesen, Philip Batterham (ed.)

Published : 2021

Abstract

The majority of excitatory neurotransmission in the insect brain occurs via nicotinic acetylcholine receptors (nAChRs), however knowledge of which nAChR subunits may be required in specific neurons is virtually absent. The ubiquity of nAChRs in the insect brain also makes them ideal molecular targets for many neuroactive insecticides. Mutations in specific nAChR subunits can confer high levels of resistance, but the fitness costs that may be associated with resistance alleles or with low-dose insecticide exposure are not fully understood. This thesis examines two Drosophila nAChR subunits with the most severe loss of function phenotypes, with a focus on their endogenous functions and their r..

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University of Melbourne Researchers