Thesis / Dissertation

The biological characterization of circulating osteoprogenitor cells and their role in geriatric musculoskeletal disease

Jack Thomas Feehan, Gustavo Duque (ed.)

Published : 2021

Abstract

Circulating Osteoprogenitor (COP) cells are a relatively newly identified population of musculoskeletal precursor cells in the peripheral circulation. While some evidence has shown their capacity for osteogenic differentiation, there is little else known. Additionally, there is contradiction between studies regarding their origin – whether from the mesenchymal, or hematopoietic lineages. Research into COP cells, particularly the hematopoietic lineage, has been slowed by the lack of ability for isolation and expansion in culture – limiting understanding of their potential for use clinically. In this thesis, a model for the isolation, and expansion of COP cells is designed and validated. COP c..

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University of Melbourne Researchers