Thesis / Dissertation

Androgen receptor dysregulation in Amyotrophic Lateral Sclerosis

Victoria McLeod, Bradley Turner (ed.)

Published : 2021

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder, resulting in the death of motor neurons. Sexual dimorphism is clear in ALS patients and mouse models. Capable of modifying disease onset and progression, sex differences can also manifest in the responsiveness and outcomes to drug therapies and interventions. Understanding the biological components contributing to the clinical heterogeneity in ALS is of great interest. The androgen receptor (AR), a nuclear steroid hormone receptor which mediates the biological actions of androgens, has strong links to motor neuron function and survival. Androgens are neuroprotective to cultured motor neurons and in res..

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