Journal article
Low-dose IL-2 therapy invigorates CD8 T cells for viral control in systemic lupus erythematosus
P Zhou, J Chen, J He, T Zheng, J Yunis, V Makota, YO Alexandre, F Gong, X Zhang, W Xie, Y Li, M Shao, Y Zhu, JE Sinclair, M Miao, Y Chen, KR Short, SN Mueller, X Sun, D Yu Show all
Plos Pathogens | Published : 2021
Abstract
Autoimmune diseases are often treated by glucocorticoids and immunosuppressive drugs that could increase the risk for infection, which in turn deteriorate disease and cause mortality. Low-dose IL-2 (Ld-IL2) therapy emerges as a new treatment for a wide range of autoimmune diseases. To examine its influence on infection, we retrospectively studied 665 patients with systemic lupus erythematosus (SLE) including about one third receiving Ld-IL2 therapy, where Ld-IL2 therapy was found beneficial in reducing the incidence of infections. In line with this clinical observation, Ld-IL2 treatment accelerated viral clearance in mice infected with influenza A virus or lymphocytic choriomeningitis virus ..
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Awarded by National Natural Science Foundation of China
Funding Acknowledgements
This study was supported by the National Key Research and Development Program of China (2017YFC0909003 to D.Y.); National Natural Science Foundation of China (NSFC) grants 31530020, 91742115 (to Z.L.), 81429003 (to D. Y.), 82071813 (to J.H.), 81970759 (to T.Z.) and 81971520 (to X. S.), Peking-Tsinghua Center for Life Sciences (to Z.L.). Australian National Health and Medical Research Council (NHMRC) project GNT1085509, and the Bellberry-Viertel Senior Medical Research fellowship (to D.Y.). Beijing sciTech Program (Z191100006619114 to J.H.) and Clinical Medicine Plus X-Young scholars Project of Peking University (PKU2020LCXQ018 to J.H.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.