Journal article
Cd44v6 defines a new population of circulating tumor cells not expressing epcam
G Belthier, Z Homayed, F Grillet, C Duperray, J Vendrell, I Krol, S Bravo, JC Boyer, O Villeronce, J Vitre-Boubaker, D Heaug-Wane, F Macari-Fine, J Smith, M Merlot, G Lossaint, T Mazard, F Portales, J Solassol, M Ychou, N Aceto Show all
Cancers | MDPI | Published : 2021
Abstract
Circulating tumor cells (CTCs) are promising diagnostic and prognostic tools for clinical use. In several cancers, including colorectal and breast, the CTC load has been associated with a therapeutic response as well as progression-free and overall survival. However, counting and isolating CTCs remains sub-optimal because they are currently largely identified by epithelial markers such as EpCAM. New, complementary CTC surface markers are therefore urgently needed. We previously demonstrated that a splice variant of CD44, CD44 variable alternative exon 6 (CD44v6), is highly and specifically expressed by CTC cell lines derived from blood samples in colorectal cancer (CRC) patients. Two differe..
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Awarded by Ligue Contre le Cancer
Funding Acknowledgements
Grant INCa-DGOS-Inserm 6045; region Languedoc-Roussillon for the Chercheur dAvenir Grant; la Ligue Contre le Cancer for funding G.B. and Z.H.