Journal article
Potential biomarkers of major depression diagnosis and chronicity
AC De Menezes Galvão, RN Almeida, GM De Sousa Junior, MA Leocadio-Miguel, F Palhano-Fontes, DB De Araujo, B Lobão-Soares, JP Maia-De-Oliveira, EA Nunes, JEC Hallak, J Sarris, NL Galvão-Coelho
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2021
Open access
Abstract
Background Molecular biomarkers are promising tools to be routinely used in clinical psychiatry. Among psychiatric diseases, major depression disorder (MDD) has gotten attention due to its growing prevalence and morbidity. Methods We tested some peripheral molecular parameters such as serum mature Brain-Derived Neurotrophic Factor (mBDNF), plasma C-Reactive Protein (CRP), serum cortisol (SC), and the salivary Cortisol Awakening Response (CAR), as well as the Pittsburgh sleep quality inventory (PSQI), as part of a multibiomarker panel for potential use in MDD diagnosis and evaluation of disease's chronicity using regression models, and ROC curve. Results For diagnosis model, two groups were a..
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Awarded by Conselho Nacional de Desenvolvimento Científico e Tecnológico
Funding Acknowledgements
This study was funded by the Brazilian National Council for Scientific and Technological Development (CNPq, grants #466760/2014 & #479466/2013), and by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) (grants #1677/2012 & #1577/2013) from the Ministry of Science, Technology, Innovations and Communications, and Brazilian Ministry of Education, respectively. ACMG is supported by CAPES (Research Fellowship 88882.344060/201901). NLGC is supported by CAPES (Finance Code 001, Research Fellowship 88887.466701/2019-00) and National Science and Technology Institute for Translational Medicine (INCT-TM Fapesp 2014/50891-1; CNPq 465458/2014-9). JS is supported by an NHMRC Clinical Research Fellowship (APP1125000).