Journal article

Relationship between Circulating Lipids and Cytokines in Metastatic Castration-Resistant Prostate Cancer

Hui-Ming Lin, Nicole Yeung, Jordan F Hastings, David R Croucher, Kevin Huynh, Thomas G Meikle, Natalie A Mellett, Edmond M Kwan, Ian D Davis, Ben Tran, Kate L Mahon, Alison Zhang, Martin R Stockler, Karen Briscoe, Gavin Marx, Patricia Bastick, Megan L Crumbaker, Anthony M Joshua, Arun A Azad, Peter J Meikle Show all

CANCERS | MDPI | Published : 2021

Abstract

Circulating lipids or cytokines are associated with prognosis in metastatic castration-resistant prostate cancer (mCRPC). This study aimed to understand the interactions between lipid metabolism and immune response in mCRPC by investigating the relationship between the plasma lipidome and cytokines. Plasma samples from two independent cohorts of men with mCRPC (n = 146, 139) having life-prolonging treatments were subjected to lipidomic and cytokine profiling (290, 763 lipids; 40 cytokines). Higher baseline levels of sphingolipids, including ceramides, were consistently associated with shorter overall survival in both cohorts, whereas the associations of cytokines with overall survival were i..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Cancer Institute New South Wales


Awarded by Cancer Council New South Wales


Funding Acknowledgements

This research was funded by National Health and Medical Research Council of Australia (GNT0614296 to L.G.H.); the Cancer Institute New South Wales (10/TPG/1-04 & 2018/TPG001 to L.G.H.); the Australian Prostate Cancer Research Centre-New South Wales; the Australian Department of Health and Aging; the Cancer Council New South Wales (PG 10-01 to L.G.H.); the Victorian Government's Operational Infrastructure Support Program (P.J.M.); the Australian and New Zealand Urogenital and Prostate Cancer Trials Group's Noel Castan Fellowship (H.-M.L.); and the Twin Towns Services Community Foundation (L.G.H.). The funders had no roles in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.