Journal article

Inflammation and depression in young people: a systematic review and proposed inflammatory pathways

Yara J Toenders, Liliana Laskaris, Christopher G Davey, Michael Berk, Yuri Milaneschi, Femke Lamers, Brenda WJH Penninx, Lianne Schmaal

MOLECULAR PSYCHIATRY | SPRINGERNATURE | Published : 2021

Abstract

Depression onset peaks during adolescence and young adulthood. Current treatments are only moderately effective, driving the search for novel pathophysiological mechanisms underlying youth depression. Inflammatory dysregulation has been shown in adults with depression, however, less is known about inflammation in youth depression. This systematic review identified 109 studies examining the association between inflammation and youth depression and showed subtle evidence for inflammatory dysregulation in youth depression. Longitudinal studies support the bidirectional association between inflammation and depression in youth. We hypothesise multiple inflammatory pathways contributing to depress..

View full abstract

Grants

Awarded by NHMRC Career Development Fellowship


Awarded by NHMRC Career Development Award


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by ZonMw: The Netherlands Organisation for Health Research and Development


Funding Acknowledgements

This work was funded by a Wellcome Trust Mental Health Priority Area 'Active Ingredients' commission awarded to LS at Orygen. LS is supported by a NHMRC Career Development Fellowship (1140764), and the Dame Kate Campbell Fellowship from the Faculty of Medicine, Dentistry and Health Sciences at The University of Melbourne. CGD is supported by an NHMRC Career Development Award (141738). MB is supported by a NHMRC Senior Principal Research Fellowship (1156072). FL is supported by ZonMw: The Netherlands Organisation for Health Research and Development (project number: 636310017).