Radiation Therapy Techniques and Treatment-Related Toxicity in the PORTEC-3 Trial: Comparison of 3-Dimensional Conformal Radiation Therapy Versus Intensity-Modulated Radiation Therapy.
Bastiaan G Wortman, Cathalijne CB Post, Melanie E Powell, Pearly Khaw, Anthony Fyles, Romerai D'Amico, Christine Haie-Meder, Ina M Jürgenliemk-Schulz, Mary McCormack, Viet Do, Dionyssios Katsaros, Paul Bessette, Marie Hélène Baron, Remi A Nout, Karen Whitmarsh, Linda Mileshkin, Ludy CHW Lutgens, Henry C Kitchener, Susan Brooks, Hans W Nijman Show all
Int J Radiat Oncol Biol Phys | Published : 2021
PURPOSE: Radiation therapy techniques have developed from 3-dimensional conformal radiation therapy (3DCRT) to intensity modulated radiation therapy (IMRT), with better sparing of the surrounding normal tissues. The current analysis aimed to investigate whether IMRT, compared to 3DCRT, resulted in fewer adverse events (AEs) and patient-reported symptoms in the randomized PORTEC-3 trial for high-risk endometrial cancer. METHODS AND MATERIALS: Data on AEs and patient-reported quality of life (QoL) of the PORTEC-3 trial were available for analysis. Physician-reported AEs were graded using Common Terminology Criteria for Adverse Events v3.0. QoL was assessed by the European Organisation for Rese..View full abstract