Journal article

REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

Dingzhi Wang, Carlos S Cabalag, Nicholas J Clemons, Raymond N DuBois

GASTROENTEROLOGY | W B SAUNDERS CO-ELSEVIER INC | Published : 2021

Abstract

Chronic inflammation is a known risk factor for gastrointestinal cancer. The evidence that nonsteroidal anti-inflammatory drugs suppress the incidence, growth, and metastasis of gastrointestinal cancer supports the concept that a nonsteroidal anti-inflammatory drug target, cyclooxygenase, and its downstream bioactive lipid products may provide one of the links between inflammation and cancer. Preclinical studies have demonstrated that the cyclooxygenase-2-prostaglandin E2 pathway can promote gastrointestinal cancer development. Although the role of this pathway in cancer has been investigated extensively for 2 decades, only recent studies have described its effects on host defenses against t..

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Grants

Awarded by Hollings Cancer Center grant, Medical University of South Carolina


Awarded by Department of Health and Human Services acting through the Victorian Cancer Agency, Victoria, Australia


Funding Acknowledgements

This work was supported in part by Hollings Cancer Center grant, Medical University of South Carolina (P30 CA138313) . The authors thank the National Colorectal Cancer Research Alliance for its generous support (Raymond N. DuBois) . Carlos S. Cabalag is the recipient of, and is supported by, The Alan & Kate Gibson Research Fellowship, 2018. Nicholas J. Clemons is supported by a Fellowship (MCRF16002) from the Department of Health and Human Services acting through the Victorian Cancer Agency, Victoria, Australia.