Journal article
The Association of Age at Diagnosis of Hypertension With Brain Structure and Incident Dementia in the UK Biobank
X Shang, E Hill, Z Zhu, J Liu, BZ Ge, W Wang, M He
Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021
Abstract
Little is known about whether the association of hypertension with brain volume and dementia is modified by an individual's age at their diagnosis of hypertension. Our analysis was based on the UK Biobank with baseline data collected between 2006 and 2010. Brain magnetic resonance imaging was used to measure brain volumes between 2014 and 2019. Dementia was ascertained using hospital inpatient, mortality, and self-reported data until 2021. We randomly selected a control participant for each hypertensive participant stratified by hypertension diagnosis age using propensity score. The cohort comprised 11 399 individuals with hypertension and 11 399 controls for the brain volume analysis and 12..
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Awarded by University of Melbourne
Funding Acknowledgements
The present work was supported by the Fundamental Research Funds of the State Key Laboratory of Ophthalmology, Project of Investigation on Health Status of Employees in Financial Industry in Guangzhou, China (Z012014075), Science and Technology Program of Guangzhou, China (202002020049). M. He receives support from the University of Melbourne at Research Accelerator Program and the CERA Foundation. The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian State Government. Z. Zhu receives support from the Research Foundation of Medical Science and Technology of Guangdong Province (B2021237). The sponsor or funding organization had no role in the design or conduct of this research. The sponsor or funding organization had no role in the design, conduct, analysis, or reporting of this study. The funding sources did not participate in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the article; and decision to submit the article for publication.