Journal article

The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids

Ronnie Ren Jie Low, Wei Wen Lim, Paul M Nguyen, Belinda Lee, Michael Christie, Antony W Burgess, Peter Gibbs, Sean M Grimmond, Frederic Hollande, Tracy L Putoczki

CANCERS | MDPI | Published : 2021

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies. While immortalized cancer cell lines and genetically engineered murine models have increased our understanding of PDAC tumorigenesis, they do not recapitulate inter- and intra-patient heterogeneity. PDAC patient derived organoid (PDO) biobanks have overcome this hurdle, and provide an opportunity for the high throughput screening of potential new therapies. This review provides a summary of the PDAC PDO biobanks established to date, and discusses how they have advanced our understanding of PDAC biology. Looking forward, the development of coculturing techniques for specific immune or stromal cell population..

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Grants

Awarded by National Health & Medical Research Council of Australia


Awarded by Victorian Cancer Agency Fellowship


Funding Acknowledgements

This work was supported by the National Health & Medical Research Council of Australia (APP1098643 to TLP), the AVNER Foundation (to SG, BL, AWB, PG and TLP). TLP was the recipient of a Victorian Cancer Agency Fellowship (MCRF16009), WEHI Dyson Bequest Centenary Fellowship, and is a Sylvia and Charles Viertel Charitable Foundation Senior Medical Research Fellow. Funding from the Victorian State Government Operational Infrastructure Support Scheme is acknowledged.