Nitric Oxide Regulates Estrus Cycle Dependent Colonic Motility in Mice
Gayathri K Balasuriya, Saseema S Nugapitiya, Elisa L Hill-Yardin, Joel C Bornstein
FRONTIERS IN NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2021
Women are more susceptible to functional bowel disorders than men and the severity of their symptoms such as diarrhea, constipation, abdominal pain and bloating changes over the menstrual cycle, suggesting a role for sex hormones in gastrointestinal function. Nitric oxide (NO) is a major inhibitory neurotransmitter in the gut and blockade of nitric oxide synthase (NOS; responsible for NO synthesis) increases colonic motility in male mice ex vivo. We assessed the effects of NOS inhibition on colonic motility in female mice using video imaging analysis of colonic motor complexes (CMCs). To understand interactions between NO and estrogen in the gut, we also quantified neuronal NOS and estrogen ..View full abstract
Related Projects (1)
Awarded by NHMRC
& nbsp;This study was supported by the NHMRC grant 1006453 (JB) and an NHMRC grant to EH-Y (APP2003848).