Journal article

Sudden Cardiac Death in Systemic Sclerosis: Diagnostics to Assess Risk and Inform Management

Laura Ross, Elizabeth Paratz, Murray Baron, Andre La Gerche, Mandana Nikpour

DIAGNOSTICS | MDPI | Published : 2021

Abstract

Cardiac disease is a leading cause of death in systemic sclerosis (SSc) and sudden cardiac death (SCD) is thought to occur more commonly in SSc than in the general population. Diffuse myocardial fibrosis, myocarditis and ischaemic heart disease are all prevalent in SSc and can be reasonably hypothesised to contribute to an increased risk of SCD. Despite this, SCD remains a relatively understudied area of SSc with little understood about SSc-specific risk factors and opportunities for primary prevention. In this review, we present an overview of the possible mechanisms of SCD in SSc and our current understanding of how each of these mechanisms may contribute to cardiac death. This review high..

View full abstract

Grants

Awarded by NHMRC


Funding Acknowledgements

This research received no external funding. LR is supported by a Musculoskeletal Australia PhD Scholarship. EP is supported by a National Health and Medical Research Council (NHMRC)/National Heart Foundation (NHF) cofounded postgraduate scholarship, Royal Australasian College of Physicians JJ Billings Scholarship and PSA Cardiovascular Scholarship. ALG is supported by a NHF Future Leadership Fellowship. MN holds a NHMRC Investigator Grant (GNT 1176538).