Journal article

Zinc Supplementation with or without Additional Micronutrients Does Not Affect Peripheral Blood Gene Expression or Serum Cytokine Level in Bangladeshi Children

Thomas Hayman, Peter Hickey, Daniela Amann-Zalcenstein, Cavan Bennett, Ricardo Ataide, Rahvia Alam Sthity, Afsana Mim Khandaker, Kazi Munisul Islam, Katharina Stracke, Nawaf Yassi, Rosie Watson, Julie Long, Jamie Westcott, Nancy F Krebs, Janet C King, Robert E Black, Md Munirul Islam, Christine M McDonald, Sant-Rayn Pasricha

NUTRIENTS | MDPI | Published : 2021

Abstract

Preventive zinc supplementation provided as a stand-alone dispersible tablet, or via home fortification as multiple micronutrient powders (MNPs), has been considered a potential strategy to prevent zinc deficiency and improve health (including immune) outcomes among children in low- and middle-income countries. However, the impact of zinc supplementation on immune profiles has not been well characterized. We sought to define the effect of zinc supplementation on peripheral blood gene expression and cytokine levels among young children in Dhaka, Bangladesh. In a sub-study of a large randomized, controlled, community-based efficacy trial where children 9-11 months of age received one of the fo..

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