Journal article

Longitudinal Study of the Levodopa Motor Response in Parkinson's Disease: Relationship Between Cognitive Decline and Motor Function

Jane E Alty, Benjamin G Clissold, Craig D McColl, Katrina A Reardon, Mark Shiff, Peter A Kempster



In this prospective study of 34 patients with Parkinson's disease (PD), measurements of the short duration levodopa motor response have been performed every 3 years in defined off states. The mean time from initiation of levodopa treatment was 14.8 years, and 17 patients survived to the latest assessment stage. Off phase motor function worsened at a yearly rate of 2.2% of the maximum disability score. The magnitude of the levodopa response is well preserved as the disease progresses, and patients who developed motor fluctuations maintained better on phase motor function than nonfluctuators (P = 0.01). Ten patients, of whom 5 survive, developed dementia. There was no difference in pretreatmen..

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